Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1201-8. doi: 10.1016/j.bmcl.2013.12.092. Epub 2013 Dec 30.

Abstract

Starting from a thiazolidin-4-one HTS hit, a novel series of substituted lactams was identified and developed as dual orexin receptor antagonists. In this Letter, we describe our initial efforts towards the improvement of potency and metabolic stability. These investigations delivered optimized lead compounds with CNS drug-like properties suitable for further optimization.

Keywords: CNS drug discovery; G-protein coupled receptors; Metabolic stability; Orexin antagonists; Structure–activity relationship studies.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Drug Discovery*
  • Humans
  • Lactams / chemistry
  • Lactams / metabolism
  • Lactams / pharmacology*
  • Molecular Structure
  • Orexin Receptor Antagonists*
  • Rats
  • Rats, Wistar
  • Structure-Activity Relationship

Substances

  • Lactams
  • Orexin Receptor Antagonists